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IUI –Intrauterine Insemination or Artificial Insemination (AI)

IUI Treatment, or intrauterine insemination, is a relatively simple first line Infertility treatment. It involves a laboratory procedure to separate fast moving sperms from sluggish or nonmoving sperms. Then these washed sperms with the help of small tube are placed directly into the uterus close to the time of ovulation when the egg is released from the ovary.

The rationale is expose more oocytes to more sperms near the site of fertilization and make chances of pregnancy better. This is a minor, painless procedure of 5-7 minutes. It is also cost friendly treatment for patients, and can be repeated 3-4 times.

Prerequisites for IUI

  • Ideal age less than 40 years
  • Patient capable of spontaneous or induced ovulation
  • At least one patent fallopian tube with good tubo-ovarian relationship
  • A hostile cervical condition, including cervical mucus problem
  • Unexplained infertility
  • Ejaculatory dysfunction
  • Sperm count of more than 10 million/ml pre-wash or a post-wash count of >5million motile sperms with percentage motility of more than 40%.


Proper patient selection and work-up
  • Ovarian stimulation.
  • Monitoring of follicular growth and endometrial development.
  • Timing of insemination
  • Semen preparation
  • Intrauterine Insemination with prepared semen
  • Post IUI hormonal Support
  • Detection of Pregnancy


IUI is carried out near the time of ovulation, which is detected by Either doing TVS ultrasound or by ovulation kit. The sperm will be inseminated just before or after rupture of the follicle (ovulation).

The whole process takes just a few minutes and is usually painless but some women may experience menstruation – like cramps. Following the procedure, rest for 15 – 20 minutes is recommended before going home.


  • In male infertility cases, when sperm count is slightly low or if donor sperm is used
  • It may be used if woman’s cervical mucus is less.
  • Also in cases of unexplained infertility.
  • In cases where marriage is not consummated either due to female factor or due to erection or ejaculation disorders in man

Contraindications of IUI.

  • Blocked bilateral fallopian tubes
  • Poor sperm count or nil sperm count
  • Sereve endometriosis grade III -IV
  • women with age more than 40 years


The success rates of IUI is dependent on the woman’s age at time of treatment. The clinical pregnancy rate in women aged 36 or less is between 12-15% per treatment cycle.


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