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Role of PRP in Endometrium Rejuvenation

You don’t have to worry after seeing those scientific jargons in the heading, we at Origyn IVF always bring you up-to-date information and advances in the field of IVF treatment. Our IVF specialists have taken the responsibility of briefing you on the new method of ensuring a successful embryo transfer cycle which might increase the chances of a successful pregnancy. Today, we will enlighten you on the role of PRP in Endometrium Rejuvenation.

We will talk about what is Platelet Rich Plasma, what is Endometrium Rejuvenation, The stages of PRP, and also, discuss whether it is a safe option or not. Our IVF experts will share their expertise on how this procedure can assist you to fulfil your dream of becoming a parent and hopefully, by the end of this blog, you will have a clear understanding of PRP treatment and its benefits in Endometrium Rejuvenation.


PRP Treatment

Firstly we need to understand actually Platelet-Rich Plasma Treatment means, this is one of the new methods of increasing the chances of a successful embryo transfer cycle. In this treatment, the platelets-rich blood plasma is collected from the female patient only which contains a wide variety of growth factors. There are multiple growth factors which play a vital role in the process of endometrium rejuvenation and about that our IVF specialists will talk ahead of this. These growth factors help in cell growth and regeneration of tissues.

Endometrium Rejuvenation

Before we head towards discussing the process of endometrium rejuvenation, we must understand what endometrium is. Endometrium is the lining of the uterus and its physiological functions are preparation for implantation, maintenance of pregnancy if implantation occurs, and menstruation in the absence of pregnancy. Therefore, the endometrial growth must be adequate if you want a successful cycle and eventually, pregnancy. The process of endometrium rejuvenation is recommended for females who have inadequate or less endometrial growth and this is where PRP treatment helps.

As we mentioned in the above passage about growth factors, platelet-rich plasma which is formulated during PRP treatment has all of those growth factors like vascular endothelial growth factor, platelet-derived growth factor, epidermal growth factor and many other growth factors with other cytokines. These growth factors and cytokines help in the rejuvenation and growth of the endometrial tissues and thus, increasing the thickness and helping in successful embryo transfer. Hence, most IVF experts recommend this treatment as it helps in the regeneration of endometrial tissues and cell growth, which eventually, increases the chances of a successful embryo transfer cycle.

Platelet rich plasma (PRP) is well prepared from fresh whole blood which is collected through a peripheral vein, kept in acid citrate dextrose solution A (ACD-A) anticoagulant and processed to enhance platelets by separating different parts of blood. Through activating platelets in PRP, cytokines in addition to growth factors (GFs) turn out to be bioactive and are released within 10 mins right after clotting. These factors consist of vascular endothelial growth factor (VEGF), transforming growth factor, platelet derived growth aspect, and epidermal growth factor. They can regulate cellular migration, attachment, proliferation plus differentiation, and promote extracellular matrix accumulation. Nowadays, PRP continues to be widely applied in several clinical scenarios like orthopedics, ophthalmology, and injury healing to enhance tissue reconstruction. However, little is recognized about the application of PRP in the treatment of thin endometrium.

PRP planning during lining preparation for embryo transfer

The infusion of PRP is painless procedure. Platelet rich plasma PRP is instilled into the uterine cavity immediately with catheter (0.5-1 ml). Endometrial thickness is re-assessed seventy-two hours later. If the particular endometrial thickness is not necessarily satisfied, infusion of PRP can be performed again for 1-2 times.

Safety Concerns

Being one of the best IVF centers in Delhi, we at Origyn IVF can understand that new medical treatments can have doubts and concerns related to their safety. But, when it comes to PRP treatment you can go ahead with it without any doubt as this process includes the usage of your own blood through which platelet-rich plasma is made. Thus, the question of side effects does not arise.
There have been numerous case studies and experiments already done and they all showed that PRP treatment is safe and doesn’t have any allergic reactions or symptoms. Hence, you should not worry about the safety of this procedure.

However, IVF specialists at Origyn IVF highly recommend consulting an experienced IVF expert as every human body is different and before, going forward you should consult a specialist. You can always reach out to us as we are one of the best IVF center in Delhi, with the latest technology and certified IVF specialists. If you still have any doubts relating to this treatment you can contact us at 08080809084 or book an appointment.


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