Home » Oocyte Cryopreservation
As we know unlike in case of men a women’s reproductive life is limited by age. So if a decides to postpone getting pregnant either due to personal/professionals reasons or medical reasons. Oocytes Banking is exciting technology, it has really change a life of lots of women. The intention of the procedure is to secure future fertility by preserving their eggs just like Diana Hayden (Miss World) did.
Egg freezing: Girls who are suffering from cancer and have to undergo chemotherapy and radiotherapy can get their eggs freezed . Over 50000 reproductive age women are diagnosed with cancer each year in US. This number is higher in India. As chemotherapy and radiotherapy are toxic for oocytes and in these therapies the ovary can be damaged so egg freezing offers women with cancer to preserve their eggs to utilize them in attempt to have children in the future.
Early Menopause: A women with a family history of early menopause. Turness Syndrome (a chromosomal abnormality that comes with a risk of premature ovarian failure). Or a genetic mutation that leads to decline in ovarian reserve or removal of ovary may be the last option.
Premenopausal is a time of transition –the change of life – Your ovaries are starting to produce less estrogen & progesterone. LH & FSH levels are starting to rise as your ovaries are ecoming less responsive to them.
Career – Career oriented women and girls nowadays are busy with their life so are opting for late marriages .So some of these girls before the age of 35 do come forward and freeze the oocytes so than even if they wish to have a child in their 40’s these oocytes can be thawed and used for conception.
Social-Egg freezing: Egg freezing for the purpose of preserving fertility for delayed hildbearing when natural conception becomes more problematic. Even now many MNC companies are too providing egg freezing facility to unmarried girls, so that if they are doing justice with their job in the mean time would lose the chance to have their own baby due to low ovarian reserve.
Before beginning the egg-freezing process, counselling of patient is done and screening blood test is advised like AMH(anti mullerian hormone) and viral markers (HIV, HBSAG, HCV, VDRL).
During a normal menstrual cycle only one follicle is produced by ovaries but since we want to preserve as many eggs as possible. Ovaries are stimulated with injections( gonadotrophins) to produce multiple eggs. These are used in conjunction with drugs like antagonist for proper regulation of the cycle.
These scans are done regularly to assess follicular development. The size of the follicles indicates the degree of egg maturity, usually 10-15 follicles will develops in the ovaries during standard stimulation protocol.
All the instructions prior to the oocytes retrieval or egg pickup will be given on the day women receives trigger injection(usually GnRH agonist for final maturation of oocytes). The trigger injection is usually given late evening or in the night so as to schedule the pickup in morning around 34-36 hrs later. Aspiration of ovarian follicles under anaesthesia is done in OT adjacent to the IVF laboratory. This is done by trans-vaginal ultrasound technique. For this procedure a probe is inserted in to vagina and this project a picture into a monitor which enables the doctor to direct a needle into each follicle to retrieve the eggs. The fluid filled follicles are aspirated under slight suction in a test tube which is passed on to the embryologist.
The embryologist locates the Egg and places them into culture media and then into the incubator. After the procedure the women will have to rest in hospital for 3-4 hours. It is a day care procedure.
In a 2013 meta-analysis of more than 2,200 cycles using frozen eggs, scientists found the probability of having a live birth after three cycles was 31.5 % for women who have frozen their eggs at age 25, 25.9 % at age 30,19.3 % at age 35 and 14.8 % at age 40.
The risks for women undergoing egg freezing includes