• Bulletin Board
    • Dr. Rashmi Sharma
    • has been conferred with prestigious
    • Medical excellence Award
    • on the eve of Republic day 25.1.2014 at IMA hall for her
      exemplary contribution in the field of reproductive medicine.
origyn fertility and ivf centre delhi
    +91-9717252619
         +91-8929115454
   info@origynivf.com

Advanced IVF Technology – a boon for humanity and for cancer survivors

Lisa ray (a cancer survivor) gave birth to twin girls by surrogacy.

There are very few advancement like IVF  which have impacted the overall quality of life so much for so many couples.

In India only, approximately 27 million couples are facing the curse of being infertile. Going by statistics approximately one in every 7-8 couple is facing this issue.

Egg freezing is the upcoming biggest technological advancement in the field of ART.

This technique has given the opportunity to a single women /cancer patient to delay motherhood .as cancer survival rates are now quite good, we should try to preserve the fertility of young men and women suffering from various types of cancer who are about to lose their fertility due to cancer treatment.

Origyn Fertility and IVF center is one of the most renowned centers for fertility preservation in India. We are the referral centre for cancer patients from Rajeev Gandhi Cancer Institute, Max, Shalimar Bagh and Action Balaji hospital on a regular basis. Almost daily, we are preserving sperms of young boys and men.

Now with increasing awareness of various fertility preservation options for women as well, we are being approached by parents of many young girls as well.

Social egg freezing also is increasingly being requested by many women, who are planning to delay childbearing, either due to unavailability of the suitable partner or due to cancer issues.

Some multinational companies like facebook and google have even started sponsoring for egg freezing for their female employees.

Cost of egg /embryo freezing  (either for delaying childbearing or prior to cancer treatment  ) is almost like an IVF cycle that in between 1.5 lakh rupees to 2 lakh rupees.

At Origyn Fertility and IVF, we are increasingly getting more and more women who want to freeze their eggs. Mostly these women are in their thirties.

This technology is the answer for  “Ticking Biological Clock ”and very useful when faced with a dilemma of choosing between career, and having a baby or waiting for the right partner without bothering about ticking biological clock.

Are IVF babies same as naturally born babies?


IVF In-vitro Fertilisation (Test Tube Baby) is a boon for childless couples, but with its advancements still, a few stigmas are associated with it. People have myths in mind regarding the procedures of IVF and also about the resulting child from it. As they think whether the baby is as normal as a normal baby, are they free from any kind of deformities? The first IVF baby Louis Brown who was born in 1978 and she is the example that she is herself now a mother of the baby child. It is high time to bust the most common myth that IVF babies are different from naturally conceived ones. Although conception of the IVF babies is not natural, it is out of women’s body in a petri dish of an embryology lab, but with the advanced technology and medical expertise the results of the artificial conception are at par with the natural conception.

In case of IVF, the egg is fertilized by the sperm (Male Partner) in a lab under the supervision of skilled and experienced embryology team and IVF doctors. A certain level of embryo growth takes place in the Embryology lab and once the embryo has reached the right stage in its development, it is placed in the female partner’s uterus, after which the growth and entire pregnancy carry on as it would have been as in natural conception. Couples with fertility issues opt for IVF because either the male or female partner or (in some cases, both partners) has a fertility issue that prevents natural conception. 

While it is true that in IVF, the doctor inserts the embryo into the uterus of the female through the cervix, from that point on, the pregnancy is like any other. So we must bear in mind that the technology used is referred to as Assisted Reproductive Technology (ART), not Artificial Reproductive Technology.

Whether it is natural conceived baby or IVF conceived baby chances of abnormalities are same. IVF babies are as healthy as other babies, nobody can tell a difference between an IVF baby and a naturally conceived baby. For all the couples facing fertility issues, it is advised not to believe in myths blindly. so it is advised to take this crucial decision after doing research and gain knowledge of IVF, instead of blindly believing in myths associated with it. They must consult a good expert IVF specialist doctor to clarify all their doubts and then only proceed further.

IVF babies are as normal as other children. In fact, until one is told, it is impossible to distinguish between IVF baby and other children.

Case Study: IUI Positive Pregnancy at Very Poor Egg Reserve AMH (0.17 ng/ml)!

Our patient Mrs. Aditi (name changed to protect privacy of the patient) 38-year-old patient, married for 2 years had been advised donor egg IVF cycle at multiple places.  When she came to Origyn IVF, she was very distressed and wanted to conceive with her own eggs desperately.

We explained to her that for donor egg IVF there is no age limit, so she will have that option open to her even if comes to us 5-10 years later and since she has not yet attained menopause and less than 40 years of age, she should definitely be trying with her own eggs. 

So we gave her simple egg forming oral medication followed by few more ultrasounds to track her follicle growth.

She formed a very nice follicle in her left ovary at approximately 20mm size of follicle.

She was given an injection for follicle to rupture and after 36 hours of that injection Intra Uterine Insemination (IUI) was done with husband’s semen.

17 days later, she could not believe when her Urine Pregnancy Test (UPT) came positive.

In this patient she had been married only for 2 years (late marriage – not that she was infertile for long period of time) and her tests like Tube Test, Ultrasound,  husband’s Semen Analysis were normal except for extremely poor AMH (Anti mullerian Hormone – 0.17 ng/ml).

AMH tells us how much reproductive life span a lady has like in this woman, definitely she had very little time left, but she was still forming few eggs and had not completely exhausted her reserve.

Such patients should be given a chance to conceive from their own egg by simple measures like: IUI or Natural Cycle IVF – before finally proceeding for donor egg IVF if no conception.

Such positive result at extremes of situation give us impetus to try harder and harder for our patients and give them best result with minimum medication and treatment.

Case Study – Life doesn’t end in 50’s, it’s never too late to become a mother

One of the story of our patient will make you believe that even miracles take a little time to happen.  Life doesn’t end in 50’s, it’s never too late to become a mother.

Our patient Mrs. Rajni (name changed to protect privacy of the patient) 50 year female came to us with previous 3 IVF failures along with thin endometrium and fibroids in uterus.  She had a history of 3 year menopause and known case of hypertension.

After loosing hope to get pregnant through various IVF treatment she was completely shattered and came to us with a ray of hope.

Patient was counseled and told that due to her Poor Ovarian Reserve along with thin endometrium and fibroids in uterus she has to go for donor egg IVF and the success rate of IVF in her case in < 50%.

She gave a history of long estrogen therapy given to prepare her uterus for embryo transfer but in spite of this uterine lining never thickened beyond 6.5mm.

Knowing a fact that pregnancy can risky at her age as she was known case of hypertension we told her to go under a full  health checkup under which certain test were done like: Chest X-Ray, ECG blood investigation (Haemogram, Blood sugar, LFT, KFT, Lipid Profile, ETC)

After screening all her reports we started donor egg IVF

Her treatment protocol that was followed:

  • First Frozen Embryo transfer cycle was abandoned because on the day of transfer fluid was seen in the endometrium.
  • In second Frozen Embryo transfer cycle we used heparin, G-CSF to prepare the endometrium and embryo glue was used at the time of FET.

After using all the experimental techniques when patient came to us after 12 days she gave us good news with positive B-HCG Reports.  Now she is carrying a singleton pregnancy.

Are you suffering from fibroid uterus?

Uterine fibroids are benign (non-cancerous tumors) that originate in the uterus.  They usually develop during the childbearing age of women, and most common genital pathology found in this age group.

Symptoms of uterine fibroids:

Most of the time women with fibroids are unaware of its presence, as it does not lead to any symptoms.

But in some women it can lead to:

  • Abnormal uterine bleeding (heavy menses) especially when a fibroid protrudes into the uterine cavity, it can cause erosion of endometrium (uterine cavity) lining.
  • Prolonged periods
  • Pain in lower abdomen
  • Anemia due to heavy bleeding.

 

Other Symptoms are based on the size and location of the fibroids in the uterus.

  • Dyspareunia (difficulty in intercourse )
  • Pelvic pain
  • Rectal pressure that causes difficulty in defecation
  • Frequent urination due to bladder irritability.

In some cases if the fibroids are affecting the endometrium lining than it may lead to infertility also.

Sometimes fibroids can cause blockage of the opening of fallopian tubes into the uterus that may lead to infertility.

Treatment:

  • Small asymptomatic fibroids especially if not affecting the lining of uterus do not require any treatment and should just be followed.
  • Large fibroids and submucosal fibroids (those which interfere with the lining- endometrium) need to be removed prior to starting fertility treatments such as IVF, in order to decrease the chances of implantation failure, miscarriages, other pregnancy complications.
  • Medical treatment – If patient desires fertility these medicines are not useful as these will prevent conception:
  1. NSAIDS : Decrease the amount of bleeding and pain
  2. Hormones : New medication like -Mifepristone/ Ulipristal are available and may help in some cases to buy time before surgery.

Conclusion: Mostly no treatment is needed if you are not suffering from any symptoms.

Are you worried about Low sperm count?

A condition in which sperm count is lower than normal is called as oligospermia.

Generally it is considered when the sperm count is <15 million sperm/ml.When there is no sperm that condition is called as azoospermia.

Usually low sperm count is in association with low motility and abnormal shapes of sperm as well.

A couple trying to have a baby for more than 1 yrs, yet not able to conceive, than low sperm count may be the reason for not conceiving.

In such situations couple should consult an infertility specialist consultant.

Causes of low sperm count

In about 50% cases no cause can be found,  in rest following may be present:

  • Heat: Increased temperature in scrotal region by any mean (for example sauna bath, wearing tight clothes, exposure to heat at work place, keeping Laptops in lap for long periods etc)
  • Obesity: Abdominal fat in excess also increases the scrotal temperature
  • Addiction: smoking and alcohol
  • Medical condition like varicocele
  • Genetic factors
  • Certain in generalized drugs &illnesses
  • Use of anabolic steroids for muscles building.

Treatment for low sperm count

To avoid heat: wear loose cotton clothes instead of tight clothes, minimize the exposure to heat

Avoid keeping Laptop in Lap

Stop addiction like smoking and alcohol.

Some vitamins & antioxidants also may help in Low Sperm count.

Finally in case of low sperm count and low sperm motility ART (Assisted Reproductive Technology) should be use to facilitate conception by IUI (Intra uterine insemination) or by IVF ICSI (Intracytoplasmic Sperm Injection).

For more queries contact us at: 9717252619 / 011-40105555
www.origynivf.com, www.drrashmisharma.com

Best infertility doctor in Pitampura/  Best IVF Centre in Rohini/ ICSI treatment in Delhi/ Low cost IVF treatment in Delhi/ What is low Sperm count/ low sperm count treatment/ Best infertility specialist in Delhi

Male Infertility

There are certain taboo topics for men in society in which one of them is male infertility.

Infertility is defined as: Inability to conceive after 1 year of unprotected sexual intercourse. Although in our society it is assumed that infertility is the problem of women.

Male infertility refers to inability of male partner to cause pregnancy in female partner. It is affects 7% of all men and contributes to 30% of all infertility cases.

Male Infertility

 

male fertility cause

Causes of Male Infertility

Male fertility generally relies on the quantity and quality of his sperm which gets affected by certain causes.

  1. Medical Causes
  2. Environmental Causes
  3. Psychological causes
  4. Lifestyle causes
male fertility cause
male fertility cause

 

Diagnosis of Male Infertility:

Male infertility can only be diagnosed by semen analysis in a good Lab.

male fertility cause

Treatment of male infertility:

ivf and icsi treatment

Treatment mainly depends on the causes of male infertility like:

  1. Surgery: In case of Varicocele
  2. Infections: Antibiotic
  3. Erectile dysfunction: Medication and counseling needed to a patient
  4. ART Treatment: In this sperm is obtained through normal ejaculation or through surgical extraction (TESE/ PESE) or from donor individual where sperm are less in amount.

Origyn – Twin IVF babies after 8 IVF Failures including 4 miscarriages

Donor egg

These babies (twins) , Origyn babies were born in the very first successful attempt at Origyn IVF one of our case study of March 2017.

Mrs. Vandana (name changed ) 43 Years female came to us with previous one ectopic pregnancy 8 IVF failures : 4 Self egg & 4 donor egg and along with 4 miscarriages (all IVF pregnancies). She had lost all hopes of delivering a baby on her own and came to us seeking surrogacy. After screening all her reports, she was told to undergo tests for so many miscarriages and then proceed with whatever treatment is decided by them in consultation with Dr. Rashmi Sharma. The patient had poor ovarian reserve also her AMH was < 1.0 along with male factor (Oligoasthenozoospermia).

Below mentioned investigation and treatment protocol was followed for them

 

Donor egg IVF-ICSI was advised

Before proceeding towards IVF certain customized protocol was followed like
Donor egg

These steps were taken to improve pregnancy outcome as the patient had experienced many pregnancy losses before.

  1. Endometrial scratching: the endometrium is gently scratched with a cannula to make it more receptive to embryo implantation. It is an OPD procedure.
  2. Embryo Glue : In case of previous IVF failures a new culture media is giving promising results.
  3. Heparin: An anticoagulant used in cases of thromboptic disorders.

After all these measures Vandana delivered a baby boy and baby girl little pre-mature at 32 weeks through C- section in March 2017. Now she is a proud mother of 2 babies.

Origyn Fertility & IVF feels proud to announce that one more feather has been added to our success stories of couples . Our endeavor to cater such multiple IVF failure and highly complicated cases gives us confidence and contentment which is unexplainable
So contact with highly experienced Dr Rashmi Sharma ( IVF Specialist ) info@origynivf.com

Recurrent Pregnancy Loss (RPL)

“No matter how much time passes there will always be this hollow place deep inside that throbs for the one who is gone.”

Pregnancy loss occurs in 10 to 15% of all pregnancies, of which 1-2% are recurrent. The World Health Organization (WHO) has defined miscarriage as the loss of a fetus weighing <500g, which would normally be at 20-22 complete weeks of gestation.

Recurrent abortion is traditionally defined as three or more consecutive miscarriages occurring before 20 weeks.

ASRM guidelines suggest two or more clinical miscarriages (Ultrasound Documented) but may not be consecutive.

When to start testing?

(Do we wait for 3 abortions before start testing?)

  1. No at 2 abortions we can start testing the causes of recurrent pregnancy loss
  2. In some cases even at 1 abortion testing is done like:
    1. If women is older >35 years
    2. Pregnancy after infertility treatment.

Causes of Recurrent Pregnancy Loss:

Genetic causes

  • 2-4%
  • Associated with parental chromosomal abnormality in which most common cause is balanced translocation.

Infectious Factor

  • 0.5%
  • Toxoplasma gondii, rubella, HSV, measles
  • Direct infection to the uterus, foetus or placenta

Immunological Factor

  • 3-5%
  • Antiphospolipid syndrome

Anatomic factor

  • 10-15%
  • Endometrial factor
  • Congenital uterine anomalies
  • Intrauterine adhesions
  • Uterine fibroids or Polyp
  • Other mullerian anomalies like: unicornuate, didelphic, bicornuate
  • Asherman syndrome

Endocrine factor

  • 17-20%
  • luteal phase defect
  • PCOS
  • Diabeties
  • Thyroid disease
  • hyper prolactinemia

Environmental Factor

  • Exposures to
    1. Smoking
    2. Alcohol
    3. Caffeine

Diagnosis of Recurrent Pregnancy loss

Diagnosis evaluation mainly includes:

Karyotypes of POC/ parents

Uterine Anatomy (evaluation by 3D USG/ Hysteroscopy)

Evaluation of Thyroid Dysfunction

Testing For Diabetes

Antiphospolipid Syndrome

Selected Thrombophilias

Conditions

Some of the treatments used in recurrent pregnancy losses are

1. Antiphospolipid Syndrome thrombophilia. Ecosprin & Heparin

ANTICOAGULANT DRUGS are used

2. Parental Chromosomal abnormality: Treatment may be either use of donor gametes or IVF with PGD

3. Unexplained recurrent pregnancy loss: No proven treatment yet available for unexplained reasons but lot of clinical trials are going on for immune therapy / G-CSF Therapy etc.

4. Progesterone Support

For such patients three magical words needed are:

Studies have shown in patients of RPL that Tender LovingCare (TLC) is equally effective as other experimental treatments.

Origyn Fertility & IVF, winner of Best IVF clinic award have dealt with many complicated cases of recurrent pregnancy loss in a very comprehensive manner. Our aim is to give couple’s hope turn into reality.

So don’t lose hope have a second opinion/advice from Dr Rashmi Sharma, an international name in Infertility & IVF, contact today or mail us at info@origynivf.com

Save Girl Child

“Beti Bachao Beti Padao”
“Beta beti ek samaan”
“If daughters are not born where will u get daughter in laws”
“If you kill a daughter you kill a mother , a sister, a daughter and many more relations too”
These are few slogans heard these days with awakening launch of nationwide campaign of “Save Girl Child” by our Hon’ble Prime Minister Shri Narender Modi ji. This has opened the eyes of society with the true facts of dropping ratio of boys versus girls i.e 10 : 7 which is an alarming signal for Indian social setup . Many celebrities and learned people have joined hands for it to make this campaign a success. Madhuri Dixit is the brand ambassdor for this project. Below is the story of my own childhood memories , which is itself an example of that girls are not curse and no less than boys.
Now being a IVF specialist , if I recall back at my own personal story and my childhood memories I feel on the top of the world to have been blessed with good parents . I have been brought up in a middle-class family setup, from a very small town of U.P , Khekra, but very lucky to have such a open minded and educated parents for whom we four sisters were not a burden.They made education our weapon and we all succeeded in our career. We were provided with all oppurtunities that are given to boys. I was always inclined to study in science stream but in our girls school there was no science , so I was admitted in boys school which was a revolutionary step itself in small town , khekra , and soon other girls of our town joined me in that school . I completed my higher secondary with a place in UP Board’s merit list than got into BHU for my MBBS and after that did all my higher studies further. My other sisters too are doing best in their career my parents have proven in Khekra that ,if we are dertermined no one can stop us to achieve the goal. Today my parents are very proud of their 4 daughters and say that they are the happiest persons in the world.My intention to convey that we should give equal oppurtunities to girl child and girls make parents much happier than any boy will do.

IVF TREATMENT